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Autoantibody/HLA Service Center

Services Overview


Islet Autoantibody Tests

Insulin Autoantibodies (mIAA): 
A micro insulin autoantibody radiobinding assay with the result expressed as an index against the laboratory standard internal positive and negative controls. The patients using exogenous insulin will all be positive.

GAD65 Autoantibodies (GAA):
It is a NIH/NIDDK harmonized GAD65 autoantibody radiobinding assay with the result expressed as DK units/ml with a NIDDK standard curve. The test result is comparable with all ongoing NIH/NIDDK led national/international clinical trials like TrialNet, TEDDY study, etc.

IA-2 Autoantibodies (IA-2A):
NIH/NIDDK harmonized IA- autoantibody radiobinding assay with the result expressed as DK units/ml with a NIDDK standard curve. The test result is comparable with all ongoing NIH/NIDDK led national/international clinical trials like TrialNet, TEDDY study, etc.

ZnT8 Autoantibodies (ZnT8A):
A ZnT8 autoantibody radiobinding assay with the result is expressed as an index against the laboratory standard internal positive and negative controls.

Other Autoantibody Tests

Transglutaminase Autoantibodies (TG):
TG is a well known autoimmune marker for Celiac disease and multiple studies have demonstrated that the TG levels are strongly associated with clinical disease onset by biopsy. Among the patients with type 1 diabetes, around 8-10% are TG positive. TG test is a radiobinding assay and the result is expressed as an index against the laboratory standard internal positive and negative controls.

21-Hydroxylase Autoantibodies (Hyd21):
Hyd21 is a specific autoimmune marker for Addison’s disease. Many patients were initially found to have the disease because of the autoantibody screening. Among the patients with type 1 diabetes, around 1-1.5% are Hyd21 positive. Hyd21 test is a radiobinding assay and the result is expressed as an index against the laboratory standard internal positive and negative controls.

HLA Typing:
We accept either whole blood (fresh or frozen) or DNA samples. 
HLA DQA&B Typing
HLA DRB1 Typing
HLA A Typing
HLA B Typing

All clinical diagnostic samples will be assigned our BDC LabID and PtID upon receipt. The patient information will be entered into our BDC laboratory main database including all test results. The database is secured and has back-up system through University of Colorado IT Services. All test results will be stored long-term and will be retrievable.

Turn-Around Time

Autoantibody Services: Within one week
HLA Services: Within two weeks

Location:
Barbara Davis Center
University of Colorado, Anschutz Medical Campus
1775 Aurora Court, 4th floor, Room M20-4201E
Aurora, CO 80045
Tel: 303-724-6809
Fax: 303-724-5811

Autoantibody/HLA contact personnel:
Liping Yu, MD, Principal Investigator & Core Director
Tel: 303-724-6808

The purpose of this website is to provide some basic information about the BDC Service Cores including contact information and links to on-line services where they are available. If you have questions about the BDC Service Cores please contact us (email or phone: 303-724-6836).