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Welcome to the Barbara Davis Center for Diabetes at the University of Colorado School of Medicine on the Anschutz Medical Campus in Aurora, Colorado.

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Research Division Faculty


  Tomasz Sosinowski, PhD
  Primary Appointment: Instructor, Department of Pediatrics


My research focuses on understanding the role T cells play in the development and progression of Type 1 Diabetes (T1D). This builds upon my previous studies of T Cell Receptor (TCR) signaling and thymocyte development (Dr. Art Weiss lab), regulation of interlekin-15 expression (Dr. John Kappler and Dr. Philippa Marrack lab), and of the biology of insulin-specific T cells derived from NOD mice (Dr. Laurent Gapin lab). I joined the BDC in 2011 with the goal of extending these studies to humans. As originally proposed by my former mentor George Eisenbarth, a fundamental cause of T1D in NOD mice and potentially in humans, is the recognition of proinsulin–derived peptides bound to the “diabetogenic” MHC molecules by“diabetogenic” CD4+ T cells (that form critical trimolecular complexes: insulin/MHC/TCR). I am therefore, focusing on immune responses to proinsulin, and in particular on the regions of the beta chain (residues 9-23) and C-peptide (residues 41-62) previously shown by others to be presented by HLA-DQ2, DQ8, and the DQ8/DQ2 trans-dimer. 

My current work focuses on two projects:
(1) Development of a humanized Mouse Model for preclinical testing of agents that target components of human tri-molecular complexes (e.g. small molecules and antibodies).
(2) Creation of an improved Biomarker Assays based on standardized artificial Antigen Presenting Cells (aAPCs) that selectively and specifically enumerates T cells recognizing proinsulin-MHC complexes. Such improved biomarker assays are urgently needed for more accurate monitoring of therapeutic efficacy during clinical interventions.


PhD, University of California, San Francisco (2001)

Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact: Kathryn Gray