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Research Division Faculty



Tomasz Sosinowski, PhD
Instructor, Department of Pediatrics
University of Colorado School of Medicine

Barbara Davis Center for Diabetes
Biosketch

My major scientific interest is to understand the role T cells play in causing Type 1 Diabetes (T1D). This builds upon my previous studies of T Cell Receptor (TCR) signaling and thymocyte development, and of the molecular interactions between the TCR of insulin-specific diabetogenic T cells derived from NOD mice, and their cognate ligand (I-Ag7 displaying the insulin B:9-23peptide). In 2011 I joined the Barbara Davis Center for Diabetes (BDC) with the goal of extending these studies to humans. Currently I am focusing primarily on developing “register fixed” HLA-DQ8:insulin peptide tetramers which I expect will become the basis of improved bioassays to monitor disease risk and progression. I am also playing a key role in other BDC studies focused on isolating and cloning antigen specific T cells recognizing T1D autoantigens, with particular emphasis on reconstitution of candidate human TCRs that can recognize insulin or ZnT8. Identification of disease relevant TCRs, definition of their HLA restriction, and a detailed knowledge of the molecular interactions with their cognate ligands, are all prerequisites for understanding T1D pathology. This knowledge should enable us to identify new therapeutic targets to prevent or arrest disease, and to generate innovative bioassays to monitor therapeutic efficacy in patients with T1D.

Publications list:

Nakayama M, Castoe T,  Sosinowski T, He X, Johnson K, Haskin K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS. Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice. Diabetes. 2012 Feb 7[Epub ahead of print]. PMID 22315318

Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A. Src-like adaptor protein regulates TCR expression on thymocytesby linking the ubiquitin ligase c-Cbl to the TCR complex.  Nat Immunol. 7(1):57-66, 2006. PMID: 16327786

Sosi

nowski T, Killeen N, Weiss A.  The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.  Immunity 15(3):457-466, 2001. PMID: 11567635

Sosi

nowski T, Pandey A, Dixit VM, Weiss A.  Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med. 191(3):463-74, 2000. PMC2195826

Pub Med Publications by Tomasz Sosinowski

To access a more complete listing of publications, please go to PubMed http://www.ncbi.nlm.nih.gov/PubMed/ and use the search term Barbara Davis Center for Childhood Diabetes or enter individual author names.
Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact:Kathryn Gray