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Research Division Faculty

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Liping Yu, MD
Primary Appointment: Assistant Research Professor of Pediatrics

L. Yu, L. Jiang, D. Tobin, D. Miao, T. Armstrong, S. Staggs, R. Wang

Our clinical immunology laboratory is an NIH/NIDDK designated Autoantibody/HLA Core laboratory. We have developed several autoantibody assays that demonstrate high sensitivity and disease specificity with applications in national/international type 1 diabetes clinical trials and screening projects. Our lab serves as the core laboratory for Type 1 Diabetes TrialNet, The Environmental Determinants of Diabetes in the Young (TEDDYand the Immune Tolerance Network (ITN) consortia.
Our major interests are focused on humoral autoimmune responses and HLA genetics in Type 1 Diabetes. Islet autoantibodies (currently known to insulin, GAD65, IA-2, and ZnT8) usually appear years before clinical onset of type 1 diabetes, therefore they are very important markers for islet autoimmunity and play an essential role in prediction, prevention, and clinical practice for diagnosis and treatment for type 1 diabetes. HLA is well known as a susceptible gene marker for type 1 diabetes. Early detection of islet autoantibodies and HLA genetic analysis helps to study the natural history of the disease to try and understand the interaction between environmental aspects and immune system/genetics which are important for studying the etiology of type 1 diabetes. In collaboration with the DAISY study, our laboratory has defined the genes associated with childhood diabetes. Type 1 diabetes is also associated with other autoimmune diseases, mostly thyroid, celiac and Addison’s disease. We have studied celiac disease through transglutaminase autoantibody testing and Addison’s disease using 21-hydroxylase autoantibodies. Our laboratory helps to routinely screen all BDC patients for the associated autoimmune conditions.

Lab Members:
Principal Investigator: Liping Yu, MD
Research Associate: Dong Mei Miao
Professional Research Assistant: Taylor Armstrong
Professional Research Assistant: Ling Jiang
Professional Research Assistant: Deng "Rona" Wang

Autoantibody/HLA Service Center:
Core Director: Liping Yu, MD
Laboratory Manager: Taylor Armstrong

MD: Jiangsu University Medical School, China (1981)

Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact: Kathryn Gray, BFA, MA​