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Welcome to the Barbara Davis Center for Diabetes at the University of Colorado School of Medicine on the Anschutz Medical Campus in Aurora, Colorado.

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Research Division Faculty

Janet M. Wenzlau, PhD, Instructor

Wenzlau, J.M., Juhl, K., Yu, L., Moua, O., Sarkar, S., Gottlieb, P., Rewers, M., Eisenbarth, G.S., Jenson, J., Davidson, H.W., and Hutton, J.C. The Cation Efflux Transporter ZnT8 (Slc30A8) is a Major Autoantigen in Human Type I Diabetes.  (2007).  Proceedings of the National Academy of Science  104(43):  17040-5. PMID 17942684.

Wenzlau, JM, Hutton, JC, Davidson, HW  (2008).  New Antigenic Targets in Type 1 Diabetes. Current Opinions in Endocrinology, Diabetes, and Obesity 15(4): 315-20. PMID 18594270.

Wenzlau, J.M., Yu, L., Sarkar, S, Moua, O., Rangasamy, S., Walters, J., Eisenbarth, G.S., Davidson, H.W., Hutton, J.C. (2008).  A Common Non-synonymous Single Nucleotide Polymorphism in the Slc30A8 Gene Determines ZnT8 Autoantibody Specificity in Type 1 Diabetes. Diabetes 57(10): 2693-7. PMID 18591387.

Kawasaki, E., Uga M., Nakamura, K., Kuriya, G., Satoh, T., Fujishima, K., Ozaki, M., Abiru, N., Yamasaki, H., Wenzlau, J.M., Davidson, H.W., Hutton, J.C., and Eguchi, K. (2008).  Association Between Anti-ZnT8 Autoantibody Specificities and Slc30A8 Arg325Trp Variant in Japanese Patients with Type 1 Diabetes. Diabetologia 51(12):2299-302, PMID 18850084.

Wenzlau, J.M., Moua, O., Sarkar, S.A., Yu, L., Rewers, M., Eisenbarth, G.S., Davidson, H.W., and Hutton, J.C. (2008).  Slc30A8 is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes. Annual New York Academy of Science 1150:256-259. PMID 19120307.

Liu, Y., Wenzlau, J.M., Yu, L., Patel, C., Eisenbarth, G.S., Hutton, J.C., and Davidson, H.W. (2008).  Conserved Epitopes in the Protein Tyrosine Phosphatase Family of Diabetes Autoantigens. (2008). Annual New York Academy of Science 1150:.245-247. PMID 19120304.

Wenzlau, J.M., Moua, O., Liu, Y., Eisenbarth, G.S., Hutton, J.C., and Davidson, H.W. (2008). Identification of a Major Humoral Epitope in Slc30A8 (ZnT8). Annual New York Academy of Science 1150:252-255. PMID 19120306.

Wenzlau, JM, Frisch LM, Gardner TJ, Sarkar S, Hutton HC, Davidson HW (2009) Novel antigens in type 1 diabetes:  the importance of ZnT8. Curr Diab Rep. ;9(2):105-12, PMID:  19323954

Wenzlau J.M., Sheridan L., and Hutton J.C. Discovering Novel Antigens. Imunoendocrinology: Scientific and Clinical Aspects edited by George S. Eisenbarth 2009.

DeGrijse J Asanghanwa M, Nouthe B, Albrecher N, Goubert P, Vermeulen I, Van Der Meeren S, Decochez K, Weets I, Keymeulen B, Lampasona V, Wenzlau J, Hutton JC, Pipeleers D, Gorus FK; (2009)  the Belgian Diabetes Registry. Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. Diabetologia. 2010 Mar;53(3):517-24. PMID 20091020

Wenzlau J.M., Walter M., Gardner T.J., Frisch L.M., Yu L., Eisenbarth G.S., Ziegler A.G., Davidson H.W., Hutton J.C. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. (2010) Journal of Clinical Endocrinology and Metabolism 95(10):4712-9. PMID: 20610599.

Yang L., Luo S.M., Huang G., Peng J., Yan X., Wenzlau J., Davidson H.W., Hutton J.C., Zhou Z.G. Zhonghua Yi Xue Za Zhi. (2010) Value of zinc transporter 8 antoantibody in the diagnostic classification of acute-onset diabetics. Zhonghua Yi Xue Za Zhi 90(36):2536-40. PMID: 21092458.

Yu L, Liu Y, Miao D, Wenzlau J, Davidson H, Hutton J, Eisenbarth GS. Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination. J Immunol Methods. 2010 Feb 28;353(1-2):20-3.

Dang W, Rockell J, Wagner R, Wenzlau JM, Yu L, Hutton JC, Gottlieb PA, Davidson HW. (2011) Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.  May 15;186(10):6056-63.  PMID:  21471440

Wenzlau JM, Frisch LM, Hutton JC, Davidson HW. (2011)  Mapping of conformational autoantigody epitopes in ZnT8.  Diabetes Metab Res. Rev. 2011

Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC. (2011) Development of a Novel Autoantibody Assay for Autoimmune Gastritis in T1D Individuals. Diabetes Metab Res. Rev. 2011 In Press

Vermeulen I, Weets Ik, Asanghanwa M, Ruige J, Van Gaal L, Mathieu C, Keymeulen B, Lampasona V, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK, The Belgian Diabetes Registry (2011)  Contribution of Antibodies Against IA-2{beta} and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 years of Age. Diabetes Care.  Jun29

To access a more complete listing of publications, please go to PubMed and use the search term Barbara Davis Center for Childhood Diabetesor enter individual author names.Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please