Edwin Liu, MD
Assistant Professor in Pediatrics
Section of Gastroenterology, Hepatology and Nutrition
The Children's Hospital, Denver
BioSketch
Study into the mechanism of peptide-based immunotherapy using a major autoantigen, insulin peptide B:9-23. Development of a potential vaccine to prevent type 1 diabetes using B:9-23 peptide.
Investigation into mechanisms of self-peptide anaphylaxis from immunotherapy. Development of methods to prevent peptide-induced anaphylaxis to make immunotherapy safer.
The immunologic role of tissue transglutaminase as the major autoantigen in celiac disease.
Publications:
Devendra D, Miao D, Nakayama M, Eisenbarth GS, Liu E.
Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse.
Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E.
Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout.
Diabetes. 2006 Jul;55(7):1978-84.
Liu E.
Genetic testing for celiac disease.
MLO Med Lab Obs. 2006 Jan;38(1):10-3;
Devendra D, Jasinski J, Melanitou E, Nakayama M, Li M, Hensley B, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E.
Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes.
Diabetes. 2005 Sep;54(9):2549-56.
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Nature. 2005 May 12;435(7039):220-3.
Liu E, Rewers M, Eisenbarth GS.
Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?
Gastroenterology. 2005 Apr;128(4 Suppl 1):S33-7.
Liu E, Li M, Bao F, Miao D, Rewers MJ, Eisenbarth GS, Hoffenberg EJ.
Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified children.
J Pediatr. 2005 Apr;146(4):494-9.
Devendra D, Paronen J, Liu E, Moriyama H, Taylor R, Miao D, Yu L, Eisenbarth G.
Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes.
Ann N Y Acad Sci. 2004 Dec;1029:331-3.
Devendra D, Paronen J, Liu E, Moriyama H, Miao D, Yu L, Eisenbarth GS.
Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse.
Ann N Y Acad Sci. 2004 Dec;1029:328-30.
Melanitou E, Devendra D, Liu E, Miao D, Eisenbarth GS.
Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset.
J Immunol. 2004 Dec 1;173(11):6603-10.
Liu E.
Peptide-specific amelioration of T cell-mediated pathogenesis in murine type 1 diabetes.
Clin Immunol. 2004 Oct;113(1):1-2.
Liu E, Moriyama H, Abiru N, Paronen J, Devendra D, Finkelman FD, Eisenbarth GS.
Preventing peptide-induced anaphylaxis: addition of C-terminal amino acids to produce a neutral isoelectric point.
J Allergy Clin Immunol. 2004 Sep;114(3):607-13.
Liu E, Yu L, Moriyama H, Eisenbarth GS.
Animal models of insulin-dependent diabetes.
Methods Mol Med. 2004;102:195-212.
Paronen J, Liu E, Moriyama H, Devendra D, Ide A, Taylor R, Yu L, Miao D, Melanitou E, Eisenbarth GS.
Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes.
Aly T, Devendra D, Barker J, Liu E, Yu L, Eisenbarth GS.
Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetes.
Diabetes Care. 2004 May;27(5):1205-6.
Rewers M, Liu E, Simmons J, Redondo MJ, Hoffenberg EJ.
Celiac disease associated with type 1 diabetes mellitus.
Endocrinol Metab Clin North Am. 2004 Mar;33(1):197-214, xi. Review.
Devendra D, Liu E, Eisenbarth GS.
Type 1 diabetes: recent developments.
BMJ. 2004 Mar 27;328(7442):750-4. Review.
Liu E, Bao F, Barriga K, Miao D, Yu L, Erlich HA, Haas JE, Eisenbarth GS, Rewers MJ, Hoffenberg EJ.
Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease.
Clin Gastroenterol Hepatol. 2003 Sep;1(5):356-62.
Abiru N, Sun F, Kawasaki E, Yamasaki H, Oshima K, Nagayama Y, Mizuguchi H, Hayakawa T, Miao D, Liu E, Eisenbarth GS, Eguchi K.
In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice.
Ann N Y Acad Sci. 2003 Nov;1005:218-21.
Paronen J, Moriyama H, Abiru N, Sikora K, Melanitou E, Babu S, Bao F, Liu E, Miao D, Eisenbarth GS.
Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background.
Ann N Y Acad Sci. 2003 Nov;1005:205-10.
Melanitou E, Liu E, Miao D, Yu L, Glimcher LH, Eisenbarth G.
Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.
Ann N Y Acad Sci. 2003 Nov;1005:187-91.
Liu E, Moriyama H, Paronen J, Abiru N, Miao D, Yu L, Taylor RM, Eisenbarth GS.
Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse.
J Autoimmun. 2003 Nov;21(3):213-9.
Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, Devendra D, Beilke J, Gianani R, Gill RG, Eisenbarth GS.
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10376-81. Epub 2003 Aug 18.
Eisenbarth GS, Moriyama H, Robles DT, Liu E, Yu L, Babu S, Redondo MJ, Gottlieb P, Wegmann D, Rewers M.
Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes.
Autoimmun Rev. 2002 May;1(3):139-45. Review. Erratum in: Autoimmun Rev. 2006 May;5(5):364.
Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, Finkelman FD, Eisenbarth GS.
Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23.
J Clin Invest. 2002 Oct;110(7):1021-7.
Liu E, Eisenbarth GS.
Type 1A diabetes mellitus-associated autoimmunity.
Endocrinol Metab Clin North Am. 2002 Jun;31(2):391-410, vii-viii. Review.
Liu E, Abiru N, Moriyama H, Miao D, Eisenbarth GS.
Induction of insulin autoantibodies and protection from diabetes with subcutaneous insulin B:9-23 peptide without adjuvant.
Ann N Y Acad Sci. 2002 Apr;958:224-7.
Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, Gianani R, Wong FS, Eisenbarth GS.
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide.
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5539-44.
To access a more complete listing of publications, please go to PubMed http://www.ncbi.nlm.nih.gov/PubMed/ and use the search term Barbara Davis Center for Childhood Diabetesor enter individual author names.
Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact:
kathryn.gray@ucdenver.edu