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Women, insulin and sex hormones


This study plans to learn more about the menstrual cycle and heart disease in women with type 1 diabetes compared to women who do not have diabetes. It involves 5 study visits-- a screening visit and 4 visits that span a menstrual cycle-- at the Barbara Davis Center. The screening visit is to ensure eligibility in the study. The first menstrual cycle visit is a fasting visit that will take 1½ to 2 hours at the beginning of your cycle. The final 3 visits are non fasting blood draws that span the rest of the menstrual cycle. Additionally, a continuous glucose monitor is inserted at the first and third menstrual cycle visits and is worn for 7 days at a time. Up to 180 people from the Denver area will participate in this study.

You may be eligible if you are:

  • Age 18-40 and premenopausal
  • Not currently using hormones (oral contraceptives, contraceptive patch, norplant, Depo-Provera, post-menopausal hormones)
  • Not currently pregnant or planning to become pregnant in the next 3 months
  • No recent history of amenorrhea (no menstrual period for at least 3 months)
  • Menstrual cycle between 25-35 days on average
  • Normal thyroid function (can be treated)
  • Diagnosed with type 1 diabetes for at least 5 years
  • Put on insulin within a year of diagnosis and on current insulin therapy
  • HbA1c < 9.5
  • Normal kidney function (urinary albumin excretion rate < 200 µg/min)

There is an additional insulin sensitivity study which is optional, and involves an overnight stay at University Hospital and a metabolic study from 7 am – 3pm.

Compensation is provided for all study visits.

For more information or to schedule a screening visit, please contact:

Talia Brown, Research Assistant 303-724-7506
Rachel Sippl, Research Assistant 303-724-7505
Janet Snell-Bergeon, Principal Investigator 303-724-6762
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