Skip to main content
Sign In

Clinical Research: TrialNet Oral Insulin Study for the Prevention of Type 1 Diabetes

The Oral Insulin Trial is screening relatives of people with type 1 diabetes. Family members enrolled in the Natural History Study can see if they are eligible to participate in this prevention study.

Who can be screened?

First degree relatives: brothers, sisters, mothers, fathers, offspring (ages 1-45, inclusive)

Second degree relatives: cousins, nieces, nephews, ½ brothers and sisters, grandchildren (ages 1-20 inclusive)

Note: the relative with diabetes needs to have been diagnosed before the age of 40 and started on insulin within the first year of diagnosis.

How are relatives screened and for what?
A simple blood test is done looking for diabetes-related autoantibodies. These antibodies may appear years before type 1 diabetes develops. Relatives of people with type 1 diabetes have about a 3-4% chance of testing positive for the antibodies associated with diabetes. There is no cost for this test.
What happens if I do have autoantibodies?
In order to be eligible for the Oral Insulin Trial you must be positive for certain antibodies. If you do qualify then you will have the opportunity to join this prevention trial. Additional tests will be required along with taking a capsule filled with either placebo or oral insulin crystals.
Why is the Oral Insulin Trial being done?
The Oral Insulin Trial is being done to determine if taking oral insulin crystals delays the onset of type 1 diabetes. A previous study called DPT-1 showed that taking oral insulin may delay diabetes in certain people. The Oral Insulin Trial is being done to see if we get the same results. The study hopes to provide a way to delay or even prevent diabetes from developing. This study also provides close monitoring to individuals at risk for developing type 1 diabetes.

Whom should I contact with questions or to schedule an appointment?

TrialNet website: