| PREVENTION TRIALS |
| TrialNet: Natural History Study of the Development of Type 1 Diabetes |
Relatives of people with type 1 diabetes: 1st degree blood relatives ages 1-45 and 2nd degree relatives ages 1-20. |
| Primary Intervention with Mucosal Insulin for Prevention of Type 1 Diabetes: Pre-POINT |
Children who do not have diabetes; ages 2 to 7 years old.
Have at least one brother or sister or both parents with type 1 diabetes. |
TEDDY (The Environmental Determinants of Diabetes in the Young)
View TEDDY STUDY DVD here. |
Newborns with no family history of Type 1 diabetes. Young siblings and offspring of persons with type 1 diabetes. NO LONGER ENROLLING NEW SUBJECTS. |
| TrialNet: Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes |
Previously screened in the Natural History Trial, and identified high-risk for the development of Type 1 diabetes. |
| TrialNet: TN10 Anti-CD3 (Teplizumab) Prevention |
Relatives, ages 8-45, of people with type 1 diabetes who have been screened through the Natural History Study who have been to be at increased risk for developing Type 1 Diabetes Mellitus |
| Twin Family Study of Islet Cell Autoimmunity |
Identical and fraternal twins and triplets who are affected with type 1 diabetes and their unaffected co-twins, non-twin siblings, and parents. Type 1 diabetes in the affected twin defined as onset < age 40 and use of daily insulin therapy within one year of diagnosis. Affected twin with onset ≥ age 40 may be included if documented by the presence of islet cell auto antibodies. Twins who are concordant for type 1 diabetes may be included in the study if one twin was tested for auto antibodies prior to the development of diabetes, as may be the case for subjects in DPT-1 or TrialNet. |
| Determinants of Macro vascular Disease Risk in Adolescents With Type 1 Diabetes |
Type 1 diabetes diagnosis for at least 5 years. Ages 12-19 AND controls - adolescents without any diabetes ages 12-19. |
| Wish |
This study plans to learn more about the menstrual cycle and heart disease in women with Type 1 Diabetes compared to women who do not have diabetes. |
| INTERVENTION TRIALS |
| Metabolic Control Study |
JUST DIAGNOSED with Type 1 diabetes, Enrollment within 7 days of insulin start |
| AAT: Alpha1-Antitrypsin |
Type 1 diabetes recent onset, 6-16 years old.
Enrollment complete |
| T1DAL (Type 1 Diabetes and Alefacept) |
Diagnosed with type 1 diabetes within the past 3 months, ages 12-35 |
| RETAIN STUDY: a research trial of Aralast in new-onset type 1 diabetes |
Diagnosed with type 1 diabetes within the past 3 months, ages 8-35
Phase 1: Enrollment complete
Phase 2: coming 2012 |
| ATG-GCSF: Reversing type 1 diabetes after it is established: A pilot safety and feasibility study of Thymoglobulin and Neulasta in established type 1 diabetes |
Ages 16-45 with a diagnosis of Type 1 diabetes for at least 4 months but less than 2 years |
| Effect of Antithymocyte Globulin (ATG) on Preserving Beta-Cell Function in New Onset Type 1 Diabetes Mellitus |
Type 1 diabetes diagnosis within 100 days.
12-35 years old. Enrollment complete
|
| Vytorin And Simvastatin Trial (VAST) |
Children with type 1 diabetes between the ages of 12-22 years with elevated cholesterol and no other serious medical problems. |
| TolerX (TTEDD) Cohort 5 |
Enrollment Complete |
| Randomized Study of Real-Time Continuous Glucose Monitors in the Management of Type 1 Diabetes |
Enrollment Complete
|
| Effects of GAD on the Progression of Type 1 Diabetes in New Onset Subjects (The GAD65 Research Study) |
Enrollment Complete |
| DEFEND-I: Phase 3 Trial of Otelixizumnab for Young Adults With Newly Diagnosed Type I Diabetes Mellitus |
Enrollment Complete |
| Phase II trial of hOKT3g1(Ala-Ala), Teplizumab, for treatment of patients with recent onset Type 1 diabetes mellitus (Delay Study) |
Enrollment Complete |
| AbATE Type 1 Diabetes Trial for New Onset Diabetes |
Enrollment Complete |
| TrialNet: Effect of CTLA-4 Ig (Abatacept) on the Progression of Type 1 Diabetes in New Onset Subjects |
Enrollment Complete |
| Phase I Study of BHT-3021 in Subjects with Type 1 Diabetes |
Enrollment Complete |
| TolerX Type 1 Diabetes Trial |
Enrollment Complete |