Colo. – Scientists, led by researchers at the University of
Colorado School of Medicine, have developed the first animal model for studying
paralysis caused by virus linked to a polio-like illness that paralyzed 120
children in 2014.
with mice in the laboratory of Kenneth Tyler, MD, chairman of the Department of
Neurology, Alison Hixon, an MD/PhD candidate at the CU School of Medicine, and
a team of researchers were able to demonstrate that several strains of the
virus, known as enterovirus D68, or EV-D68, recovered during the 2014 epidemic
can cause a paralytic illness in mice that resembles several aspects of the
is a really important breakthrough as it gives us a model to both study
therapeutics and to understand how the disease develops,” Tyler said. The
results are published in the Feb. 23 edition of PLOS Pathogens, a peer-reviewed
online open-access journal.
the fall and winter of 2014, the United States experienced an epidemic of acute
flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak
of EV-D68 respiratory disease. EV-D68 had previously been a rare cause of
illness in the United States. Up to half of the 2014 AFM patients had RNA from
EV-D68 detected in their respiratory secretions. The connection between EV-D68
and AFM led to the current research studies.
appears as sudden onset of limb weakness, similar to polio, and medical imaging
tests often reveal damage within the nervous system, particularly in the spinal
cord. The effects of AFM can be devastating, leaving victims permanently
disabled. Since 2014, the Centers for Disease Control and Prevention has been
actively investigating the illness and has continued to receive reports of
sporadic cases of AFM. In 2016, a total of 132 people in 37 states across the
country were confirmed to have AFM.
are currently no established treatments for EV-D68,” said Hixon. “A mouse model
is an important first step in screening potential drug and vaccine therapies.
Our results suggest that that there may be potentially effective strategies to
treat or prevent EV-D68 and that’s particularly important because we saw a
surge in AFM cases in 2016.”
addition to Hixon and Tyler, the co-authors of the article are Guixia Yu of the
University of California San Francisco, J. Smith Leser of the University of
Colorado School of Medicine, Shigeo Yagi of the California Department of Public
Health, Penny Clarke, PhD, of the University of Colorado School of Medicine and
Charles Y. Chiu, MD, PhD, of the University of California San Francisco.
research was supported by grants from the U.S. National Institutes of Health
and U.S. Department of Veterans Affairs. It was also supported in part by
grants from the University of California San Francisco (UCSF)-Abbott Pathogen
Discovery Award. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.