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Center for Native Oral Health Research

Statistics Core

William G. Henderson, M.P.H., Ph.D.


The purpose of the CNOHR statistics core is to provide biostatistical​ support to CNOHR investigators in protocol design, implementation of their studies in the American Indian populations, writing of procedures manuals, planning for data collection and management, data entry and transmission of data to the main data coordination center for the NIDCR Early Childhood Caries Collaborative at University of California San Francisco (UCSF), and providing the final statistical analyses in support of the study publications.  Staff in the CNOHR statistics core work closely with each study principal investigator and study coordinator in all aspects of the conduct of their studies.


The staff of the CNOHR statistics core include William G. Henderson, MPH., PhD, Director;  Angela Brega, PhD, Social Psychologist and Measurement Specialist; Joan O’Connell, PhD, Health Economist; Gregory Schaffer, BA, IT Manager; and Jacob Thomas, MPH, Biostatistician.  Many of the staff of the CNOHR statistics core have served on the work groups across the three Early Childhood Caries (ECC) Centers at San Francisco, Denver, and Boston and NIDCR in developing common measures and protocols for various aspects of the CNOHR studies.  Dr. Henderson has served on the caries outcome work group; Dr. Brega has served on the measurement workgroups defining the common and unique measures of dental knowledge, attitudes, and behaviors, and other measures of moderators and mediators; and Dr. O’Connell has served on the economics workgroup defining the dental utilization and cost measures.

Past and Current Projects

Dr. Henderson worked closely with the study investigators for RC1 and RC2 in translating their original grants into protocols for clinical trials using the standardized NIDCR clinical trials protocol template, and have helped the investigators in gaining approvals of their protocols by the tribal partners, by NIDCR and by the Colorado Multiple Institutions Review Board (COMIRB).  Dr. Henderson also worked closely with the study investigators in preparing their presentations at the meetings of the Data and Safety Monitoring Board on October 22, 2009 and June 12, 2012, in developing the manuals of operations and the data collection forms for the studies, in developing the randomization procedures for RC1 and RC2, and in training field staff for conducting the studies. Dr. Henderson is currently coordinating the publications committee for publications emanating from the RC1 ACASI and MI pilot studies, and from the RC2 baseline data.

Dr. Brega has participated on the work group to define the dental knowledge, attitudes, and behaviors and psychosocial measures across the 3 ECC centers.  These measures include measures which are common and essential among the 3 ECC centers, other measures which are highly recommended to be collected, and then measures which are unique to CNOHR.  Dr. Brega has been working closely with Mr. Schaffer in programming these measures into an ACASI system (Automated Computer Assisted Survey Interview) for data capture in the field.  She has also developed a publications plan to publish the pilot and baseline ACASI measures.

Dr. O’Connell is participating on the economics work group across the 3 ECC centers in defining the cost effectiveness protocol, and the common measures that will be collected related to dental utilization and costs.  She has also been working on the design of time-motion studies to help provide costs for the interventions, and a study using Indian Health Service computer records in determining the accuracy of self-reported data on dental utilization.

Mr. Thomas has been working on analyses in support of CNOHR publications. He has prepared an analysis file for the baseline RC2 data for other CNOHR analysts and graduate students to use. He has also been working on the analysis for the main RC2 baseline paper for reporting the baseline dental examination data from the Head Start children participating in the study.

Colorado School of Public Health

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