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Biostatistics and Informatics Seminars

Meetings held Wednesdays at 12:00-1:00 - lunch provided.


Year | Month | Week | Day 
From:    To:    
Start Time Title Description
5/1/2019 12:00:00 PM BIOS Seminar Series Sayan Mukherjee, Duke University Title: Modeling complex phenotypes Abstract: We consider two problems in modeling complex traits: (1) mapping epistatic traits and (2) modeling traits or phenotypes that are surfaces or shapes. We present a novel framework for mapping epistatic effects based on the idea of marginal epistasis—the combined pairwise or higher order interaction effects between a given variant and all other variants. We present a Bayesian approximate kernel regression model (BAKR) which allows us to robustly and efficiently compute the analog of effect sizes for nonlinear regression models, this effect size captures marginal epistasis. We illustrate the utility of BAKR by examining two important problems in statistical genetics: genomic selection (i.e. phenotypic prediction) and association mapping (i.e. inference of significant variants or loci). In the second half of the talk we introduce an approach based on integral geometry to model variation in shapes without requiring landmarks to correspondence maps between shapes. We apply this method to modeling variation in the heel bone of extinct and extant primates as well as predicting disease free survival in glioblastoma from the shape of tumors based on MRI data. We also present an approach to sub-shape association, given the molars of several monkeys we infer which subregions are the most variable with respect to dietary differences.
5/8/2019 12:00:00 PM BIOS Seminar Series MPH Capstone practice talks
5/15/2019 12:00:00 PM BIOS Seminar Series NO SEMINAR - finals week
 

 Past Seminars

 

Colorado School of Public Health

13001 E. 17th Place
Mail Stop B119
Aurora, CO 80045


303.724.4585
colorado.sph@ucdenver.edu

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