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Pharmacology PhD Program

Signal Transduction


Bioinformatics

The means whereby the activities of different cell types are harmonized to provide integrated responses in an organism is the key feature that allows multi-celled organisms to flourish. This coordination is achieved by the activities of a dazzling array of neurotransmitters, hormones and growth factors, which operate on timescales of milliseconds to days. The study of these processes is known as signal transduction, or cellular signaling, which is one of the key areas of biomedical research, because of what it tells us about normal functions and the therapeutic opportunities that it identifies. The department of Pharmacology has built up its strength in cellular signaling over the years to now being one of the most prominent departments in the US in this critical area. Investigators study ion channels, second messengers, growth factor-signaling and the cell cycle.

Associated Faculty

Assistant Professor
Ph.D., 2009, Univ. of California, Berkley
We are interested in dissecting the distinct functions of synaptic cell-adhesion molecules implicated in neuropsychiatric disorders and addiction in the context of disease-relevant brain circuits. Using cutting-edge multidisciplinary techniques, we are able to interrogate these molecules with cell-type and synapse-specific resolution.
Assistant Professor
Ph.D., 2009, Columbia University
Molecular Mechanisms of ion channel function. Examining structural and regulatory mechanisms of the Acid-sensing ion channels using electrophysiology, fluorescence, spectroscopy, and structural biology.
Associate Professor
Ph.D., 1996, Heinrich-Pette-Institute
Molecular memory mechanisms in cellular signal transduction and neuronal function; CaMKII and Ca2+ signaling.
Professor
Ph.D., 1987, Johns Hopkins Univ.
Structure and mechanism in gene regulation; biophysical and structural studies of protein-nucleic acid and protein-protein complexes in chromatin and bacterial pathogenesis.
Professor and Vice Chairman
Ph.D., 1995, Harvard Univ.
Organization of signaling complexes by protein kinase and phosphatase anchoring proteins; mechanisms regulating neuronal second messenger signaling in synaptic plasticity.
Professor
Ph.D., 1995, Univ. of Rochester
Parallels between normal development and tumorigenesis/metastasis, epithelial to mesenchymal transition, role of homeoproteins and their cofactors in breast, ovarian, and pediatric tumors, particularly in metastatic progression.
Professor
Ph.D., 1985, Univ. of California, San Diego
Investigating the role of MAP kinases and specific receptor tyrosine kinases in normal and transformed growth of lung epithelial cells using techniques of molecular and cell biology in lung epithelial cells and human lung cancer cell lines.
Associate Professor
Ph.D., 1998, Vanderbilt Univ.
Epigenetic regulation of heart failure; signaling and transcriptional mechanisms of muscle disease.
Professor
Ph.D., 1977, Cornell Univ.
Signaling pathways controlling growth and differentiation of vascular smooth muscle cells; Role of eicosanoids in lung cancer.
Professor
Ph.D., 1989, Univ. of Utah
G-protein linked receptors and their regulation; regulation of mRNA stability.
Associate Professor
Ph.D., 1988, Univ. of Washington
Signaling through calcium channels in neurons.
Professor and Chairman
D.Phil., 1990, Univ. of Oxford
Understanding the signaling mechanisms that control apoptosis in cancer development and during the response of tumor cells to cancer therapeutics.
Assistant Professor
Ph.D., 1999, Univ. of Washington
Study and manipulation of protein homeostasis and signaling pathways in live cells, optogenetic tools for controlling protein interactions, synthetic biology, cytosolic protein misfolding, yeast genetics/genomics.
Professor
M.D., 1979, São Paulo University of Medicine
Overall goals are to define the mechanisms of COPD pathogenesis and the molecular, cellular, and histopathological features of Pulmonary Hypertension. Our lab studies the pathogenesis of cigarette smoke induced emphysema and its underlying mechanisms, including the role of RTP-801 and adipocytokine, as well as his investigation in the pathogenesis of schistosomiasis-related pulmonary hypertension and development of targeted methods and treatment of pulmonary hypertension.
Professor
Ph.D., 1992, Colorado State Univ.
Defining the molecular signaling mechanisms regulating vascular smooth muscle cell function in the setting of vascular fibroproliferative diseases, including restenosis and pulmonary hypertension.

Contact

David Port, Program Director
Email: David Port, Ph.D.
Shanelle Felder, Program Administrator
Voice: 303-724-3565 | Fax: 303-724-3663 | Email:grad.pharm@ucdenver.edu
12800 E. 19th Avenue, Mail Stop 8303, Research Complex 1 North Tower, Room 6106, Aurora, CO 80045

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