Pepper Schedin, PhD
Professor, Medical Oncology
Education: University of Colorado, Boulder, CO-1989
University of Colorado Denver
School of Medicine, Division of Medical Oncology
12801 E. 17th Ave., MS 8117, Aurora, CO 80045
Tel: (303) 724-3873, Fax: (303) 724-3889
Dr Schedin was recruited to the clinical breast cancer program at UC Denver in 2004 for her expertise in the fields of breast cancer prevention and stromal-epithelial interactions.
The focus of my research program is on understanding epithelial-stromal interactions in normal and pathologic breast development, to investigate the modulation of these interactions by physiologic and lifestyle interventions, and develop chemoprevention strategies based on knowledge of these interactions. My lab is at the forefront of investigating the normal mammary gland microenvironment and has shown that the extracellular matrix and immune cell compliments are highly plastic, remodeling in response to various physiologic signals and lifestyle interventions. This normal stromal plasticity contributes significantly to breast cancer risk, but also identifies unique developmental windows that can be targeted for the prevention (and treatment) of breast cancer. Current areas of research include understanding how pregnancy and menopause increase risk for breast cancer. The strength in this ‘window of risk’ approach lies in the ability to limit duration of treatment, thus reducing treatment complications associated with current chemoprevention strategies. For our studies we utilize the rat MNU model, breast cancer xenograft, transgenic and newly developed immunocompetent mouse models, 3D cell culture, and human breast tissues. Our systems approach has yielded promising results for the prevention of pregnancy-associated breast cancer and for obesity-induced postmenopausal breast cancer.
• Lyons TR*, O’Brien J*, Borges V, Conklin MW, Keely PJ, Elicieri KW, Marusyk A, Tan AC, and Schedin P. Postpartum mammary gland involution drives DCIS progression through collagen and COX-2. Nature Medicine 2011 Aug 7; 17(9):1109-1116. PMIID:21822285
• O’Brien J, Martinson H, Durand-Rougely C and Schedin P. Macrophages are critical for epithelial cell apoptosis and adipocyte repopulation during mammary gland involution. Development 2012; 139(2):269-75. PMID:22129827
• O'Brien JH, Vanderlinden LA, Schedin PJ*, Hansen KC. Rat Mammary Extracellular Matrix Composition and Response to Ibuprofen Treatment During Postpartum Involution by Differential GeLC-MS/MS Analysis. J. Proteome Res. 2012; 11(10):4894-905 PMID:22897585 *Corresponding Author.
• Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS. Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer. Cancer Research 2012 Dec 7; 72(24):6490-501. PMID:23222299
• Callihan EB, Gao D, Jindal S, Lyons TR, Manthey El, Edgerton S, Urquhart A, Schedin P, and Borges VF, Postpartum Diagnosis Demonstrates a High Risk for Metastasis and Merits an Expanded Definition of Pregnancy-Associated Breast Cancer, Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x. PMID:23430224
• Holly A. Martinson, Traci R. Lyons, Erin D. Giles, Virginia F. Borges, Pepper Schedin, Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention, Exp Cell Res (2013), http://dx.doi.org/10.1016/j.yexcr.2013.04.018
NIH 1 R01 CA164166
Schedin Role on Grant: MPI with Dr. Paul MacLean
Title: A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
Goals of Project: The hypothesis tested is that obesity associated impaired metabolic regulation establishes a susceptibility to the tumor promoting effects of the menopause-induced weight gain.
NIH 1 R01 CA169175
Schedin Role: MPI w Dr. Virginia Borges
Title: NSAID during postpartum involution for breast cancer prevention
Goals of Project: Validate postpartum involution as a window of tissue remodeling in human breast. Evaluate efficacy and safety of NSAID based intervention in rodent models of pregnancy associated breast cancer and investigate anti-inflammatory activity of fish oil in the context of postpartum involution in rodent models.