Active research projects in photonics and biomedical imaging include:
- ultrafast laser technology
- nonlinear spectroscopic techniques
- optical bioengineering
Active research projects biomedical imaging include:
- medical physics
- applied electromagnetic
- nondestructive and noninvasive evaluation
- mathematical modeling and simulation
Professor Tim Lei leads the development of novel biophotonic techniques utilizing physical interactions (both linear and nonlinear) between light and biological materials (cells and tissues) to elucidate complex biological problems, such as disease pathogenesis, disease diagnostics and treatments, early cancer detections, etc.
Lei actively collaborates with researchers at the Anschutz Medical Campus, including researchers from the Departments of Medicine, Physiology, Neural Science, Ophthalmology and Radiation Oncology.
Current research projects include photodynamic therapy treatment and apparatus development; early cancer detection and imaging using nonlinear optical techniques; CARS (Coherent Anti-Stokes Raman Scattering) and SRS (Stimulated Raman Scattering) microscopy; Raman spectroscopy for biomedical molecular analysis; and photostimulation of neurons.
Our biomedical imaging research projects include novel imaging systems and sensors development for tumor detection, delineation and quantitative analysis, multi-modal image fusion, biomedical image and signal processing that involves linear applications, i.e. medical image enhancement, reconstruction and noise reduction, as well as the non-linear applications such as medical image segmentation and registration.
In addition, we investigate other medical imaging modalities, i.e. functional magnetic resonance imaging (fMRI) and MRI (a.k.a NMR), X-Ray computed tomography (CT, a.k.a CAT previously), ultrasound imaging (US) and related physics/engineering applications. In the applied electromagnetics and EM imaging fields, Professor Yiming Deng was actively involved in the development of 3-D computational models for both forward and inverse problems in electromagnetic sensors design and systems optimization at the NDE Lab (one of the top NDE groups in the country).