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$2.6 million grant to help research and treat pediatric stroke

CU, Children’s, exploring "important and understudied area"

5/19/2014
The Ewert Family

​By Dan Meyers | University Communications

AURORA, Colo. - Her son’s diagnosis bewildered Brooke Ewert.

“He had a stroke?” she recalls saying to her husband Travis. “A 3-year-old can have a stroke?”

Trevor Ewert actually may have had four of them before a team led by Tim Bernard, MD, a pediatrician at the University of Colorado School of Medicine who practices at Children’s Hospital Colorado, figured out the likely cause.

Today, Trevor is a smiling, squirmy, chatty 8-year-old, focused on his pet frogs and mastering flip turns in the swimming pool rather than on a medical condition that surprises many people.

Bernard and a team of doctors, researchers, nurses and statisticians at the Anschutz Medical Campus, now are hoping to do even better by young stroke patients such as Trevor.

In April, the American Stroke Association funded its first center in the country for pediatric stroke. The four-year, $2.6 million grant to CU, part of a $9 million package that includes two other universities working on adult stroke, is part of the American Stroke Association-Bugher Centers of Excellence in Stroke Collaborative Research.

“This is an important and understudied area,” says Richard J. Traystman, PhD, vice chancellor for research for the CU Denver and Anschutz campuses. “This grant is a big thing for the kids. We feel we can, in the end, come up with better understanding of stroke in children and innovative treatments.”

Combining research, treatment, outcomes

Traystman, who submitted the grant application, says CU is one of only a handful of medical centers in North America that focus on pediatric stroke. The grant positions CU to advance understanding of the issue through the unusual combination of research, treatment and outcomes.

The focus of the grant is on a certain type of stroke and age group –childhood arterial ischemic stroke in patients ages one month to 18 years.

In ischemic strokes, a blood clot blocks blood flow in the brain, killing “downstream” tissue within minutes. Another type, hemorrhagic stroke, occurs when a blood vessel ruptures. Strokes occur in utero or at birth, others later in life.

While adult stroke and treatment is much studied, pediatric stroke is not. Ischemic childhood stroke is rare, with some 1,000 cases a year in the United States. Children’s sees about 20 new cases a year and is following about 100 kids with ischemic stroke, Bernard says.

With little data about childhood stroke, Bernard says, caregivers borrow heavily from the adult world, knowing that they are helping but also that they face what he has called “a paucity of data” that further research can remedy.

“Children are not just little adults,” Traystman says. “So this is the beginning of understanding childhood stroke. Clearly the way we are treating kids cannot be 100 percent right. We don’t know what will come of what we discover through this new grant but I’m sure it will be different than with adults.”

For a pediatric neurologist such as Bernard, the grant is huge.

Trevor Ewert reaching for Dr. Bernard's finger

Craving the information

“We make the best decisions with the information we have,” he says. “But I find myself craving this information. I want to learn how to treat the kids I see better.”

Even the cause of stroke is different in kids and adults. With adults there are clear links to conditions such as high blood pressure. With kids, the cause often is mysterious, although  pre-existing issues such as sickle cell disease or congenital heart disease are sometimes a known cause. The consequences for kids can be lifelong and one stroke makes it more likely for another to occur.

For Trevor Ewert, the cause may have been a mishap on a trampoline.

A bouncing playmate accidentally landed on Trevor’s neck. Soon after, Trevor began suffering from severe headaches. One day, the Highlands Ranch family pulled into the parking lot of their church. Brooke and her husband Travis turned to the back seat and were horrified to see Trevor’s body stiff and immobile.

The Ewerts sought medical help. The incidents kept coming, at least four times total. Once, Travis says, Trevor’s symptoms hit so hard he thought his son was gone.

“Dad,” Trevor asked his father at one point, “when I go to heaven will you come see me?”

The case eventually came to Tim Bernard, part of the stroke group at Children’s, which began its stroke clinic in 2004 when Bernard was a fellow there.

Finding the problem

Trevor’s previous scans had revealed nothing. But Bernard pushed, sending Trevor’s scans to colleagues. On the same day, someone at University of Colorado Hospital and another in Toronto detected something in an angiogram – a bulge, hard to see because it was tucked away in a bend of a main blood vessel to the left side of the brain.

It was where the playmate had landed on Trevor’s neck. It was the kind of defect that could produce clots that would lodge deeper in the brain.

David Kumpe, MD, a medical school professor who practices at University hospital, performed surgery, inserting small coils to block blood flow to the problem area. Another blood vessel took over. Trevor hasn’t had a stroke since.

His case already has guided treatment for another child with similar symptoms. Now the grant may take matters much farther.

When they decided to go after that grant funding, Traystman, the veteran researcher, and Bernard, the clinician three decades younger, would hash things out by telephone on Saturday mornings seeking something unique and compelling, Traystman says, “so they would have to fund us.”

Pediatric stroke itself was an unusual focus for a stroke center. But the grant also was built on the capabilities of the existing Children’s hospital stroke program and CU animal research, and the multidisciplinary strengths of the Anschutz campus, home to two hospitals and five health care schools and colleges.

“We want to help”

Bernard’s focus includes the psychological aspects of helping kids with a stroke. Everybody’s different, he says. So for some 16-year-olds, a stroke that limits feeling in the right hand might not be crushing. You could drive, say, or get a job.

“But what if you are a baseball player?” Bernard asks. “Losing that ability at 16 can be devastating.

“If we better understand what is important for the individual patient we might be able to intervene in a way that is more helpful. “

The grant includes the unusual component of training led by Sharon Poisson, MD, who practices at UCH -- two trainees for two years, MDs and PhDs  four total, and pediatric animal based research in stroke led by Traystman and CU colleagues Paco Herson, PhD, and Wendy Macklin, PhD.

“Our main goal,” Bernard says, “is to help kids have a high quality of life, like Trevor does.”

“We learned a lot through our experience with Trevor,"  the boy’s mother, Brooke, says. “And we want to help any way we can.”

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Contact: ​Dan.Meyers@ucdenver.edu

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