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Dean’s Distinguished Seminar Series: Coordination of Circadian Rhythms and Metabolic Physiology


Mitchell A. Lazar, MD, PhD, Sylvan H. Eisman Professor of Medicine and Genetics, Director, Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania


Research 1 North building, in the Hensel Phelps West Auditorium

Start Date

4/15/2014 4:00 PM

End Time

4/15/2014 5:00 PM


Organismal metabolic homeostasis is accomplished by physiological functions of several metabolic tissues, including liver, muscle, and fat. The endocrine system coordinates organismal metabolic homeostasis via hormones that act on metabolic tissues to partition nutrients within a physiological range. Metabolic diseases, such as obesity and diabetes, ensue when these homeostatic systems fail. Normal metabolic physiology also displays circadian rhythmicity that likely evolved to anticipate recurrent, daily shifts between periods of inactivity/fasting and activity/feeding. The circadian nuclear receptor Rev-erb controls physiological rhythms of lipid metabolism in liver and energy metabolism in brown adipose tissue that contribute to the integration of organismal physiology. Broadcast to Heitler Hall at National Jewish Health.
A reception for attendees that immediately follows in the first-floor atrium outside the lecture hall. 

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Dean’s Distinguished Seminar Series

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15 Apr 2014 16:00


Content Type: University Event
Created at 1/15/2013 9:42 AM by Twichell, Tonia
Last modified at 3/19/2014 9:43 AM by Twichell, Tonia

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