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The CU School of Medicine is top-ranked in primary care, pediatrics and family and rural medicine. We offer degrees in doctor of medicine, physical therapy, physician assistant, medical science in anesthesiology, genetic counseling, modern human anatomy.

Molecular Biology Program
 

Faculty Overview


Molecular Biology Faculty

The research interests of the more than forty program faculty include structure and function of nucleic acids, mechanisms of DNA replication, RNA transcription and mRNA translation, the structure and function of viruses, genes and gene products controlling cell cycle progression, cell death and development, protein trafficking, signal transduction, hormone receptors, and structural biology. To study these important and exciting fields, our faculty employ experimental systems such as bacteria, viruses, yeast cells, Xenopus oocytes, Drosophila, C. elegans, human tissue culture cells, and genetically engineered mice. Our faculty also provide training in high resolution structure of proteins and RNA/DNA by x-ray crystallography and NMR. Because of the solid funding record of all participating faculty, graduate students find unlimited opportunities to perform research in an atmosphere of both guidance and freedom.

  
Research Description
Anderson, Steven
Signal Transduction by cytokine receptors, breast cancer.
Appel, Bruce
Development and repair of the vertebrate nervous system
Artinger, Kristin
Molecular, genetic, and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.
Barton, David
Enterovirus RNA replication.
Bates, Emily
The use of genetics to determine the molecular mechanisms of pediatric disorders.
Bayer, Ulli
Molecular memory and synaptic plasticity, cellular signal transduction and neuronal function, CaMKII and Ca2+ signaling.
Bentley, David
Eukaryotic mRNA biogenesis: transcription and RNA processing.
Bernt Kathrin
understanding molecular mechanisms of hematopoietic and leukemia development and the discovery of new therapeutic approaches
Bradford, Andrew
Regulation of tissue specific gene expression in response to hormonal and growth factor stimuli, characterization of fibroblast growth factor signaling in the pituitary, and the role of protein kinase C in endometrial cancer.
Britt, Steven
Visual system development and function using molecular-genetic approaches in Drosophila.
Churchill, Mair
Structural biology of gene regulatory mechanisms
Colgan, Sean
Understanding how epithelial and endothelial cells coordinate inflammatory bowel disease.
Davis, Richard
Programmed DNA elimination, novel RNAs, and RNA metabolism.
DeGregori, James

Cancer - understanding its evolution and targeting its dependencies.

Eisenmesser, Elan
Viral protein/host protein interactions and enzyme motions.
Evans, Thomas
The control of embryonic polarity.
Ford, Heide
The SIX family of homeobox genes and their role in development, cell cycle control and tumorigenesis.
Gerber, Anthony
The inter-relationship of glucocorticoid receptor signaling, inflammatory response, and lung function.
Graham, Douglas
TAM family of Receptor Tyrosine Kinases (RTKs) and how these RTKs contribute to the development and progression of human cancer
Gutierrez-Hartmann, Arthur
My laboratory focuses on two main projects: (1) elucidating the molecular mechanisms governing pituitary-specific gene expression; and, (2) determining the role of Ets transcription factors in breast cancer.
Hagman, James
Regulation of B lymphocyte - specific transcription and differentiation
Hesselberth, Jay
Genomics of gene regulation.
Holers, Michael
Signal transduction through complement receptors.
Holmes, Randall
Molecular characterization of bacterial toxins - gene regulation in pathogenic bacteria.
Hooper, Joan

Cell and tissue interactions that control development and tissue homeostasis.

Hu, Cheng-Jun
Role of hypoxic response in tumor progression and metastasis
Huang, Mingxia
Function and regulation of the DNA damage response.
Johnson, Aaron
Our work focuses on the formation and regulation of chromatin domains and their ultimate roles in the nucleus. We are particularly interested in the mechanisms of heterochromatin establishment and function.
Johnston, Mark
Functional genomics, glucose sensing and signaling.
Jones, David
How the three-dimensional structure of proteins and nucleic acids controls their biological function. NMR is used to study the structure and dynamics of biological molecules implicated in the development and progression of disease.
Jordan, Craig
The characterization and targeting of leukemia stem cells.
Kieft, Jeffrey
RNA structure and plasticity, viral RNA manipulation of host cell machines and enzymes, RNA-protein interactions, ribosome structure and function, use of RNA in engineered nanomachines, development of new tools for structural biology.
Kutateladze, Tatiana
Biochemistry and Structural Biology; determination of the three-dimensional structures of proteins implicated in cancer by NMR spectroscopy and X-ray crystallography; the study of epigenetics and deciphering the histone code; molecular mechanisms of protein-phospholipid interactions; structure-based drug design.
Liu, Changwei
The ubiquitin proteasome pathway.
Martin, Sandy
Mechanism of LINE-1 retrotransposition. Differential gene expression during hibernation.
McManaman, James
Lactation and Lipid secretion.
McMurray, Michael
Mechanisms of assembly and inheritance of dynamic macromolecular structures: Higher-order septin assemblies in budding yeast
Megee, Paul
Molecular basis of sister chromatid cohesion and chromosome segregation.
Moore, Jeff
Research description:  Molecular regulation of the microtubule network in cell division and disease
Neff, Tobias
  Epigenetic mechanisms in leukemia and normal development Clinical
     -         Acute leukemia
     -         Stem cell transplantation
     -         Developmental therapeutics
Niswander, Lee
Genetic and Cellular Control of Vertebrate Embryonic Development
Pearson, Chad
Centriole assembly and function
Prekeris, Rytis
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons.
Pyeon, Dohun
Human Papillomaviruses (HPVs)
Reis, Tânia
The Genetic Basis of Obesity and Neuronal Control of Energy Balance in Drosophila melanogaster
Reyland, Mary
Regulation of apoptosis in epithelial cells by signal transduction pathways.
Schaack, Jerome
Gene therapy vectors; adenovirus preterminal protein function in the regulation of the infectious cycle
Sclafani, Robert
The regulation of the eukaryotic cell cycle: DNA replication, repair and checkpoints important in cancer chemoprevention.
Thorburn, Andrew
Apoptosis regulation in cancer development and treatment.
Tucker, Chandra L.
Study and manipulation of protein homeostasis and signaling pathways in live cells, optogenetic tools for controlling protein interactions, synthetic biology, cytosolic protein misfolding, yeast genetics/genomics
VanDyk, Linda
Control of growth regulation and differentiation of host cells in viral infection and persistence.
Vasil, Michael
Molecular mechanisms of bacterial pathogenesis and gene regulation in procaryotes, including Mycobacteria tuberculosis and Pseudomonas aeruginosa.
Vázquez-Torres, Andrés
Understanding the role that mononuclear phagocytes play in the host response to intracellular pathogenic microorganisms
Voskuil, Martin
Mechanisms of Mycobacterium tuberculosis for survival during latent disease.
Wang, Jing
Genomic instability and cancer development; molecular mechanisms of somatic hypermutation and class switch recombination; metastasis and genomic instability.
Wang, Xiao-Jing
Head, Neck, and Skin Cancer Research
Williams,Trevor
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer.
Zhao, Rui
Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer
 Emeritus Faculty
Holmes, Kathryn
Virus receptors and their roles in virus pathogenesis and evolution.

 

Nordeen, Steven
Molecular mechanisms of steroid receptor mediated regulation of gene expression. Regulation of oncogene and mammary tumor virus transcription.

 

Maller, James
Biochemical and molecular basis of the control of cell division.