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Protocols - Open and Enrolling Studies

Treatment Naive

ACTG 5280: High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART

The study will examine the effects of high-dose vitamin D and calcium supplementation on bone mineral density in HIV-infected participants who are initiating anti-HIV therapy with efavirenz/emtricitabine/tenofovir (Atripla).

 

Experienced Patients

ACTG 5258: Phase II Study of Chloroquine for Reducing HIV-Associated Immune Action

This is a randomized, double-blind, placebo controlled study to evaluate the use of chloroquine in chronically HIV-infected patients who either have not received ARV therapy in the past 6 months, or have been on ARVs for at least 2 years.

 

ACTG 5275: Effect of Atorvastatin on Biomarkers of Inflammation and T-Cell Activation

This is a study of the effect of atorvastatin, also known as Lipitor, on inflammation biomarkers in people with suppressed HIV viral load and normal cholesterol levels.

 

Hepatitis

ACTG 5277: Safety and Activity of the HCV Entry Inhibitor ITX 5061 in Mono-Infected Adults

This study is evaluating an experiemental drug, ITX 5061, being developed to treat hepatitis C virus (HCV).

 

Non-Interventional/Misc. 

ACTG 5272: Oral HPV Shedding and Oral Warts After Starting Antiretrovial Therapy

This is a study for those who have never been on anti-HIV medication before, and are planning to start it either as part of another study or by their primary care provider. The study will look at how common oral warts and the virus that causes oral warts (oral human papillomavirus or HPV) are before and after starting anti-HIV medication.

 

Lung Microbiome Study: Alteration in Lung Microbiome in Acute and Chronic HIV Infection

This study plans to learn more about pulmonary complications of HIV/AIDS.

 

Influenza Studies

IRC 001: A Pilot Study for collection of Anti-Influenza A H1N1 Immune Plasma

IRC001 is a plasma collection study that will enroll healthy volunteers who have had the flu or received the H1N1 flu vaccine and are found to have high levels of H1N1 antibodies in their blood.

 

IRC 003: A Randomized Double-Blind, Phase 2 Study Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications

IRC003 is a study enrolling people at risk of getting severe flu.