First year coursework required of all graduate students in any of the Basic Science graduate programs consists of the 5-part Biomedical Sciences Core Course, 3 Research Rotations, Seminars and Ethics in Research.
Specific to the Structural Biology Program, STUDENTS MUST TAKE 2 OF THE 3 STRUCTURE COURSES; BMST 7350, 7354 or 7454 during the Spring Semester of their first and/or second year:
BMST 7350 Proteins (3 credit hours) - provides the chemical and physical basis for protein structure, folding, function and stability. Presents methods and principles of protein/peptide purification and enzyme catalysis including electron transfer and mutagenesis. The role of molecular dynamics and the use of molecular simulations in investigations of protein-ligand and protein-protein interactions.
BMST 7354 Structural Analysis of Biomolecules I (2 credit hours) - describes the fundamentals of spectroscopic methods used to study protein structure and function. These techniques include optical methods (CD spectroscopy, fluorescence and absorbance), vibrational methods (IR and ESR), analytical ultracentrifugation, mass spectrometry, calorimetry, light scattering and Biacore analysis.
BMST 7454 Structural Analysis of Biomolecules II (2 credit hours) - covers the primary structural determination and three-dimensional structures of biomolecules including proteins, carbohydrates, glycoproteins, nucleic acids and lipids. Fundamentals of high-resolution NMR and X-ray crystallography for determination of the three-dimensional structure of biological macromolecules will be included.
These three courses are taught on alternate years; Proteins one Spring and Structural Analysis of Biomolecules I and II on the following Spring. Both Structural Analysis of Biomolecules I and II are taught in the same semester with I running from Jan-Mar and II immediately following from Mar-May. Students may take either of the Structural Analysis courses without having to take both as their content stands alone. For example, to fulfill the 2 of 3 requirement, students could take Proteins and Structural Analysis II.