The Section includes many of the leading researchers in pediatric gastroenterology, hepatology and nutrition in the country. Research in the Section bridges across basic sciences, translational medicine, and clinical research related to pediatric gastrointestinal and liver diseases. Ongoing laboratory research includes investigations of the roles of cell signaling, mitochondrial dysfunction, and oxidative stress in hepatocyte injury in the cholestatic and fatty liver; the role of innate immunity in parenteral-nutrition-associated liver injury; characterization of the pathogenesis of biliary atresia in a mouse model; the role of eosinophils in cellular injury and remodeling of the esophagous and intestines; vaccine development for diabetes prevention; and mechanisms of immunologic injury in a mouse model of celiac disease.
Clinical research includes clinical trials of new therapies for hepatitis B and C; evaluation of the genetics, epidemiology and outcomes of celiac disease; investigations of the etiology and development of new diagnostics and optimal therapies of eosinophilic esophagitis; development of new therapies for fibrotic and cholestatic liver diseases; studies of bone mineral metabolism in chronic liver disease; investigation of the etiology, pathogenesis, and outcomes of biliary atresia; a clinical trial of corticosteroids in biliary atresia; a study of the cause of and a clinical trial in acute liver failure in children; diagnosis and treatment of liver disease associated with cystic fibrosis; new treatments for inflammatory bowel disease; evaluation of outcomes of pediatric liver transplant recipients; and a longitudinal study of genetic causes of intrahepatic cholestatic liver diseases in childhood.
Research at the Digestive Health Institute
Colorado Clinical & Translational Sciences Institute
Children’s Clinical Research Organization