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THOMAS L. PETTY ASPEN LUNG CONFERENCE
53rd Annual Meeting
SYSTEMS BIOLOGY OF LUNG DISEASES - PROGRESS IN THE 'OMICS' ERA
June 9-12, 2010
Mark W. Geraci, M.D., Chair
Ivor S. Douglas, M.D., Co-Chair
Stephen I. Rennard, M.D., Co-Chair
David A. Schwartz, M.D., Co-Chair

 

 

Given Institute - www.giveninstitute.org
Aspen, Colorado

In Memoriam Thomas L. Petty, M.D. (1932-2009)

The Board of the
Aspen Lung Conference
Presents the
2010 Thomas L. Petty, M.D.
Distinguished Educator Award
to Joseph Loscalzo, M.D., Ph.D.

In recognition of his lifetime of leadership in advancing the science of lung disease and educating young investigators and clinicians in the biomedical sciences.

Sponsored by
Boehringer Ingelheim Pharma, Inc.

 

Tuesday evening
Wednesday morning
Wednesday afternoon
Thursday morning
Friday morning
Friday afternoon
Saturday morning
Wednesday Poster Session
Friday Poster Session
Tuesday, June 8, 2010 -- Evening
5:00-7:00 PM Evening Registration
Wine and Cheese Reception
Given Institute, Aspen, Colorado

Wednesday, June 9, 2010 -- Morning
8:00-8:20 AM

Introduction/Welcome

Mark W. Geraci , M.D., Chair
Ivor S. Douglas, M.D., Co-Chair
Stephen I. Rennard., Co-Chair
David A. Schwartz, M.D., Co-Chair

8:20-8:30 AM

Tribute to Thomas L. Petty, M.D.
Dennis Doherty, M.D.

MODERATOR - David A. Schwartz, M.D.

8:30-9:15 AM

STATE OF THE ART
"GENETIC STUDIES OF THE ETIOLOGY OF ASTHMA ”
Kathleen C. Barnes, Ph.D.
Johns Hopkins University
School of Medicine
Baltimore, Maryland

9:15-9:30 AM Discussion

9:30-9:45 AM

IDENTIFICATION OF GENETIC LOCI IN MICE THAT MEDIATE ALLERGEN-INDUCED AIRWAY HYPER-RESPONSIVENESS, INFLAMMATION, AND SERUM IgG1.
S.N.P. Kelado 1*, D. Aylor2,1, U. Tavarez1, K. Kubalanza1, D. Carpenter1, D. Miller3, E. Chesler3,4, G. Churchill4, F.P.M.  de Villena2, D.A. Schwartz5, and F.S. Collins1.  1Molecular Genetics Section, Genome Technology Branch, National Human Genome Research Institute, NIH; 2Department of Genetics, University of North Carolina; 3Oak Ridge National Laboratory; 4The Jackson Laboratory; 5National Jewish Health.

9:45-10:00 AM

AIRWAY EPITHELIAL miRNA EXPRESSION IN ASTHMA. 
O. Solberg1, M. Love1, D.F. Choy3, L. Hou1, M. Solon1, C. Nguyen2, A.J. Barczak2, D.J. Erle1,2, J.A. Arron3, P.G. Woodruff*1,2.  1Cardiovascular Research Institute, 2Pulmonary & Critical Care Medicine, UCSF, San Francisco, and 3Genentech Inc, South San Francisco, CA.

10:00-10:30 AM Coffee Break

10:30-11:15 AM

THOMAS A. NEFF LECTURE
"GENETICS OF COMPLEX AIRWAY DISEASE"
Professor William O. Cookson, M.A., M.D.
Chair in Respiratory Genetics
National Heart and Lung Institute
Imperial College of London
London, England


11:15-11:30 AM Discussion

11:30-11:45 AM

PERIPHERAL BLOOD MONONUCLEAR CELL PROFILING IN TOBACCO EXPOSURE: SUSCEPTIBILITY MARKERS FOR COPD.
M.G. Edwards1*, M. Gruber1, C. Coldren1, R. Bowler2, M. Geraci1. 1Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, and 2Department of Medicine, National Jewish Medical and Research Center, Denver, CO. 

11:45-12:00

METABOLIC AND BIOMARKER PROFILES ASSOCIATED WITH HIGH RESOLUTION CT PHENOTYPES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD).  N. Reisdorph1, Y. Kim2, M. Armstrong1, S. Mahaffey1, R. Powell1, R. Reisdorph1, R. Bowler*2.  1Department of Immunology and 2Medicine, National Jewish Health, Denver, CO.

12:00-1:30 PM LUNCH

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Wednesday, June 10, 2009 -- Afternoon

MODERATOR: Mark W. Geraci, M.D.

1:30-2:15 PM

ROGER S. MITCHELL LECTURE
"PULMONARY ARTERIAL HYPERTENSION -
INSIGHTS FROM GENETIC STUDIES"
James E. Loyd, M.D.
Rudy W. Jacobson Professor of Medicine
Pulmonary and Critical Care
Vanderbilt University Center for Lung Research
Nashville, Tennessee

2:15-2:30 PM Discussion

2:30-2:45 PM

microRNA PROCESSING IS DYSREGULATED BY MUTATIONS ASSOCIATED WITH PULMONARY ARTERIAL HYPERTENSION.  K.M. Drake1, S.A. Comhair2, S.C. Erzurum2, and M.A. Aldred1*.  1Genomic Medicine Institute and 2Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.


2:45-3:00 PM

ACQUIRED CHROMOSOME ABNORMALITIES IN THE LUNGS OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: EVIDENCE FOR A TWO-HIT HYPOTHESIS.  M.A. Aldred1, S.A. Comhair1, M. Varella-Garcia2, K. Asosingh1, W. Xu1, G.P. Noon3, P.A. Thistlethwaite4, R.M. Tuder2, S.C. Erzurum1, M.W. Geraci2, C.D. Coldren*2.  1Cleveland Clinic, Cleveland, OH; 2University of Colorado Denver, Aurora, CO; 3Baylor College of Medicine, Houston, TX; 4University of California, San Diego, CA.

3:00-3:30 PM Break

3:30-4:15 PM

STATE OF THE ART
"IDIOPATHOIC PULMONARY DISEASE -
UPDATE ON GENETIC DISCOVERIES "
Christine Garcia, M.D., Ph.D.
University of Texas
Southwestern Medical Center
Dallas, Texas

4:15-4:30 PM Discussion

4:30-4:45 PM

DIFFERENCES IN AVERAGE AGE OF ONSET AND LOCUS HETEROGENEITY BETWEEN FAMILIAL PULMONARY ARTERIAL HYPERTENSION AND FAMILIAL INTERSTITIAL PNEUMONIA CAN PREDICT THE SUCCESS OF LINKAGE OR WHOLE EXOMIC SEQUENCING IN THE DISCOVERY OF DISEASE CAUSING ALLELES.  J.A. Phillips III1*, J.D. Cogan1, E.D. Austin1, E.K. Larkin2, C.R. Markin2, J.E. Loyd2, T.S. Blackwell2. Departments of 1Pediatrics and 2Medicine, Vanderbilt University School of Medicine, Nashville, TN.

4:45-5:00 PM

VALIDATED GENE SIGNATURES OF IDIOPATHIC PULMONARY FIBROSIS.  E.B. Meltzer*, W.T. Barry, A. Potti, P.W. Noble.  Duke University Medical Center, Durham, NC.

5:15 PM POSTER VIEWING - SOCIAL HOUR


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Thursday, June 10, 2010 -- Morning

MODERATOR: Ivor Douglas, M.D.
8:00-8:45 AM

STATE OF THE ART
"FUNCTIONAL GENOMICS IN LUNG DISEASES"
David J. Erle, M.D.
University of California, San Francisco
San Francisco, California

8:45-9:00 AM Discussion

9:00-9:15 AM

STEROID HORMONES IN ASTHMA: TOWARDS AN INTERGRATIVE MULTI-SCALE SYSTEMS BIOLOGY APPROACH.  *R.J. Freishtat1,2,3, M.C. Rose1,3, S.J. Teach2,4,  E.P. Hoffman1,3. 1Departments of Integrative Systems Biology and 2Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC; Centers for 3Genetic Medicine and 4Clinical and Community Research, Children’s National Medical Center, Washington, DC.

9:15-9:30 AM

GENOME-WIDE ANALYSIS OF TRANSLATIONAL-REGULATED GEGE IN HYPOXIA ALVEOLAR EPITHELIAL CELLS.  B. Zhou1*, D. Fan5, W. Xu2, O. Larsson3, M. Peterson1, J. Smith4, P.B. Bitterman1, D.H. Ingbar1. Department of Medicine1, Supercomputing Institute2  Biostatistics and Informatics Shared Resource5, University of Minnesota, Minneapolis, MN and Department of Biochemistry3, McGill University, Montreal, Canada and Harvard Medical School4, Boston, MA.

9:30-10:00 AM Coffee Break

10:00-10:45 AM

GILES F. FILLEY LECTURE
"GENOMIC APPROACHES IN ACUTE LUNG INJURY ”
Joe G.N. "Skip" Garcia, M.D.
Department of Medicine
University of Chicago Medical Center
Chicago, Illinois

10:45-11:00 AM Discussion

11:00-11:15 AM

PROTEOMIC ANALYSIS OF PULMONARY EDEMA FLUID FROM PATIENTS WITH ALI/ARDS REVEALS A PROMINENCE OF INTRACELLULAR PROTEINS.  L.B. Ware*, S. Sebag, J.A. Bastarache, M.A Matthay, S.L. Stamer, R.J.C. Slebos, D.C. Liebler.  Depts. of Medicine, Biochemistry and Cancer Biology, Vanderbilt University, Nashville, TN.

11:15-11:30 AM

REGIONAL DIFFERENTIAL LUNG GENE EXPRESSION ANALYSIS REVEALS NOVEL REGULATORY PATHWAYS IN VENTILATOR-INDUCED LUNG INJURY.  I.S. Douglas*1,5, S.C. Kim1,2, J.H. Cho1,3, Q. He1, A. Sergew4, D. Riches4, R.K. Albert5.  1U. Colorado, Denver, CO; 2Catholic University of Korea, Seoul, Korea; 3Inha University, Incheon, Korea; 4National Jewish Health and 3Denver Health Medical Center, Denver, CO.

12:30 PM Picnic at East Maroon Bells Portal

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Friday, June 11, 2010 -- Morning

MODERATOR: Stephen I. Rennard, M.D.
8:00-8:45 AM

STATE OF THE ART
“GENOMIC ANALYSIS OF THE AIRWAY FIELD OF INJURY ”
Avrum Spira, M.D., M.Sc.
Boston University Medical Campus
Boston, Massachusetts

8:45-9:00 AM Discussion

9:00-9:15 AM

AIRWAY GENE EXPRESSION AS A MOLECULAR PHENOTYPE OF COPD.  K. Steiling1*, P. Sebastiani1, G. O’Connor1, X. Zhang1, G. Liu1, J. Xiao1, Y. Alekseyev1, J. Campbell2, H.O. Coxson3,4, P. Pare4, J.C. Hogg4, A.M. McWilliams3, S. Lam3, D. Sin4, M.E. Lenberg1, A. Spira1. 1Boston University Medical Center, 2Boston University, 3British Columbia Cancer Agency, 4The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research.

9:15-9:30 AM

GENE EXPRESSION DIFFERENCES IN CURRENT VERSUS FORMER SMOKERS’ LUNG SQUAMOUS PRENEOPLASIA.  C. Mascaux1,7*, C. Coldren1, B. Haibe-Kains2, G. Anthoine3, A. Haller4, V. Ninane5, A. Burny6, J.P. Sculier3, F.R. Hirsch1.  1Division Medical Oncology, University of Colorado Denver, Aurora, CO, 2Functional Genomics Unit, 3Department of Intensive Care and Thoracic Oncology, 4Pathology, Institut Jules Bordet, Universite Libre de Bruxelles (ULB), Brussels, 5Department of Pulmonology, CHU Saint-Pierre, Brussels, 6Laboratory of Molecular and Cellular Biology, Faculte Universitaire des Sciences Agronomiques (FUSAGx), Gembloux, Belgium,  7Postdoctoral researcher of the F.R.S.-FNRS in Belgium, IASLC Fellowship Award, SPORE Career Development Award


9:30-10:00 AM Coffee Break

10:00-10:45 AM

REUBEN M. CHERNIACK LECTURE
"GENOMIC APPROACHES TO PERSONALIZED
TREATMENT IN CANCER"
Joseph R. Nevins, Ph.D.
Director, Institute for Genome Sciences and Policy (IGSP) Center
For Applied Genomics and Technology
Duke University Medical Center
Durham, North Carolina

10:45-11:00 AM Discussion

11:00-11:15 AM

THE HUMAN CpG ISLANDS ARRAYS REVEAL CHANGES IN GLOBAL METHYLATION PATTERNS IN IDIOPATHIC PULMONARY FIBROSIS.  E.I. Rabinovich1*, Z. Yakhini2, I. Steinfeld2, K. Pandit1, G.Yu1, L.J. Chensny1, N. Kaminski1.  1University of Pittsburgh – Pittsburgh, PA, 2Technion-Israel Institute of Technology – Haifa.

11:15-11:30 AM

GENETIC RISK FACTORS FOR LUNG CANCER IN THE ROTTERDAM STUDY: A CANDIDATE GENE STUDY.  M.E. Heuvers1,2*, K.E. van den Hondel2, R.J. van Klaveren1, A.G. Uitterlinden3, H.C. Hoogsteden, B.H.Ch. Stricker2.  1Department of Pulmonary Medicine, 2Department of Epidemiology 3Department of Internal Medicine, Erasmus Medical Center, Rotterdam.

11:30-1:30 PM Lunch

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Friday, June 11, 2010 -- Afternoon

MODERATOR: David W.H. Riches, Ph.D.
1:30-2:15 PM

STATE OF THE ART
"PROTEOMIC ANALYSIS IN LUNG CANCER"
Pierre P. Massion, M.D.
Vanderbilt University Medical Center
Nashville, Tennessee

2:15-2:30 PM Discussion

2:30-2:45 PM

BIOMARKER DISCOVERY AND VERIFICATION OF A LUNG CANGER SIGNATURE WITH SOMAMER PROTEOMIC TECHNOLOGY.  W.N. Rom*, R.M. Ostroff, H.I. Pass, W.L. Bigbee, W. Franklin, L. Gold, M. Mehan, Y. Miller, J.M. Siegfried, A. Stewart, J.J. Walker, J.L.Weissfeld, S. Williams, D. Zichi, E. Brody.

2:45-3:00 PM

METABOLOMICS IN LUNG TRANSPLANTATION: BIOMARKERS OF CHRONIC LUNG ALLOGRAFT REJECTION.  C.H. Wendt*, S. Harvey*, M. Stone*, V. Kumar*, G. Nelsestuen*.  *University of Minnesota, Minneapolis, MN

3:00-3:30 PM Break

3:30-4:15 PM

PARKER B. FRANCIS LECTURESHIP
“SYSTEMS APPROACHES TO PROTEIN MISFOLDING ”
William E. Balch, Ph.D.
The Scripps Research Institute
LaJolla, California

4:15-4:30 PM Discussion

4:30-4:45 PM

BRONCHOALVEOLAR LAVAGE PROTEIN BIOMARKERS IN CHILDREN WITH SURFACTANT DYSFUNCTION MUTATIONS; AN APTAMER PROTEOMICS APPROACH.  R.R. Deterding*1, A. Wolfson2, J.K. Harris1, J. Walker2, B.D. Wagner1, F.J. Accurso1. 1University of Colorado Denver, Aurora, CO and 2SomaLogic, Inc, Boulder, CO.


4:45-5:00 PM

ECTOPIC ACTIVATION OF EPITHELIAL DIFFERENTIATION PATHWAYS IN IDIOPATHIC PULMONARY FIBROSIS.  L. Plantier*1, S. Wert1, A. Günther2, and J. Whitsett1.  1Perinatal Institute, Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; 2Department of Medicine, University of Giessen Lung Center, Giessen, Germany.


5:00 PM POSTER SESSION - Wine & Cheese Reception

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Saturday, June 12, 2010 -- Morning

MODERATOR: Kenneth B. Adler, Ph.D.
8:00-8:45 AM

THOMAS L. PETTY LECTURE
"SYSTEMS BIOLOGY AND PERSONALIZED MEDICINE - IMPLICATIONS FOR CARDIOPULMONARY DISEASES ”
Joseph Loscalzo, M.D., Ph.D.
Hersey Professor of the Theory and Practice of Medicine
Professor of Environmental Medicine
Harvard Medical School
Boston, Massachusetts

8:45-9:00 AM Discussion


9:00-9:15 AM

THE β-CATENIN ‘TARGETOME’ IN LUNG: DYSREGULATION OF β-CANTENIN UPSETS INFLAMMATORY BALANCE IN MOUSE AIRWAY SECRETORY CELLS.  M.K. Smith*1, A.R. Lara2, C.D. Coldren2, S.D. Reynolds1, 1National Jewish Health, Department of Pediatrics, Denver, CO.  2University of Colorado School of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Aurora, CO.

9:15-9:30 AM

 

MICRORNA EXPRESSION AND THEIR TARGETS IN IDIOPATHIC PULMONARY FIBROSIS.  1G.P. Cosgrove*, 1,2I.Yang, 1S. Leach, 1,2D.A. Schwartz1,2, 1Pulmonary Division, National Jewish Health, Denver, Colorado.  2Center for Genes, Environment & Health, National Jewish Health, Denver, CO.

9:30-10:00 AM Coffee Break


10:00-10:15 AM

THE PROFIBROTIC ROLE OF MIR-154 FAMILY IN LUNG FIBROSIS.  J. Milosevic1*, K.V. Pandit1, M. Magister1, A.S. Bais2, P.V. Benos2, E. Rabinovich1, N. Kaminski1. 1Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh.  2Department of Computational Biology, University of Pittsburgh, Pittsburgh, PA.

10:15-10:30 AM

THE VIP GENE IS A DOMINANT MODULATOR OF THE PULMONARY CIRCULATION.  S.I. Said*, S.A. Hamidi. SUNY at Stony Brook, NY & VA Medical Center, Northport, NY.

10:30-11:30 PM

CONFERENCE SUMMARY
Dean Sheppard, M.D.
Professor of Medicine
Division of Occupational and Environmental Medicine
Director, Lung Biology Center
University of California, San Francisco
San Francisco, California

12:30-1:00 PM Discussion and Adjourn

 

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POSTER VIEWING -- SOCIAL HOUR Wednesday, June 9, 2010
5:00-7:00 PM - POSTERS
VIP PREVENTS AND REVERSES MONOCROTALINE-INDUCED PAH: FURTHER PROTECTION BY COMBINATION WITH BOSENTAN.  S.A. Hamidi*, A.M. Szema, S.I. Said. SUNY at Stony Brook, NY & VA Medical Center, Northport, NY.

ASTHMA AND PULMONARY ARTERIAL HYPERTENSION: TWO PHENOTYPES SHARING A KEY UNDERLYING MECHANISM?  S.I. Said*, S.A. Hamidi. SUNY at Stony Brook, NY & VA Medical Center, Northport, NY.


IDENTIFICATION OF FUNCTIONAL SINGLE  NUCLEOTIDE POLYMORPHISMS IN IL1RL1: AN ASTHMA GENE.  L. Akhabir*, A.J. Sandford. UBC James Hogg Research Laboratories.  Providence Heart + Lung Institute, St. Paul’s Hospital.  Vancouver, BC, Canada.

 

NOVEL CELL BASED ASSAYS FOR MEASURING MATRIX INCORPORATED TYPE I COLLAGEN IN LUNG FIBROBLASTS.  B. Jones, C. Bucks, P. Wilkinson, M. Pratta, F. Farrell, P. Sivakumar*, Centocor Research and Development, Radnor, PA.

 

AN ANALYSIS WORKFLOW FOR LOSS-OF-FUNCTION RNA INTERFERENCE WHOLE-GENOME SCREENING USING THE NEXT GENERATION SEQUENCING TECHNOLOGY.  T.L. Phang*†, H. Kim†, J. Kim†, D. Gao†, T. Tong¥, H. Selby†, A.C. Tan†, †University of Colorado Denver, ¥University of Colorado, Boulder, CO.

 

FAMILIAL PULMONARY FIBROSIS GENETIC COUNSELING PROGRAM: A GROUNDBREAKING PROGRAM FOR PATIENTS AND FAMILIES AT RISK FOR PULMONARY FIBROSIS, A COMPLEX GENETIC DISORDER.  J. Talbert*, K.K. Brown, D. Kervitsky. National Jewish Health, Denver, CO.

 

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COMPREHENSIVE REVIEW OF CELL JUNCTION PROTEINS IN HUMAN EPITHELIUM IN HEALTH AND DISEASE.  E.H. Chang*, A.A. Pezzulo, J. Zabner. University of Iowa Hospitals and Clinics, Iowa City, IA.

 

RISK OF CIRCULATORY DISORDERS AMONG PATIENTS WITH ASTHMA IN A LARGE INTEGRATED HEALTH CARE DELIVERY SYSTEM.  C. Iribarren1*, I. Tolstykh1, M.K. Miller2, M.D. Eisner3,1, Division of Research, Kaiser Permanente Oakland, CA; 2Genentech, Inc., San Francisco, CA; 3Division of Occupational and Environmental Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA.


BIOMARKERS OF DISEASE AND TREATMENT IN MURINE AND CYNOMOLGUS MODELS OF CHRONIC ASTHMA.  J. Louten,1 J.D. Mattson,1 M-C. Malinao,1 Y. Li,1 C. Emson,1 F. Vega,1 R.L. Wardle,2 M.R. Van Scott,2 R.B. Fick, Jr.,1 T.K. McClanahan,1 R. de Waal Malefyt,1 M. Beaumont1*, 1Schering-Plough Biopharma, Palo Alto, California and 2East Carolina University, Greenville, NC.


POTENTIAL USE OF TELOMERE LENGTH AS A SURROGATE PHENOTYPE TO DETERMINE CARRIER STATUS AND INCREASE THE GENETIC INFORMATIVENESS OF FIP FAMILIES.  J.D. Cogan*1, J.A. Phillips III1, R. Hamid1, W.E. Lawson2,  D.B. Mitchell2, C.R. Markin2, J.E. Loyd2, T.S. Blackwell2. 1Genetics & Genomic Medicine and 2Pulmonary Medicine, Vanderbilt University, Nashville, TN.

 

IMMUNE RESPONSES IN THE LUNG TO SECOND HAND CIGARETTE SMOKE. A. Kratzer*, J. Salys, and L. Taraseviciene-Stewart.  University of Colorado Denver, Department of Medicine, Denver, CO.


DISCOVERY OF LUNG CANCER BIOMARKERS BY PROFILING THE PLASMA PROTEOME WITH NASCENT MONOCLONIAL ANTIBODY LIBRARIES.

M. Guergova-Kuras1, I. Kurucz2, W. Hempel1, N. Tardieu1, J. Kádas2, C. Malderez-Bloes1, A. Jullien1, Y. Kieffer1, M. Hincapie3, A. Guttman3, E. Csánky4,5, B. L. Karger3,  L. Takács1, 2*, 1Biosystems International SAS, 4 rue Pierre Fontaine, Evry, France; 2Biosystems International Kft., Nagyerdei krt., Debrecen, Hungary; 3Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA; 4Department of Pulmonology, Medical and Healthcare Center of University Debrecen, H-4012 Debrecen, Hungary; 5Department of Pulmonology, Semmelweis Hospital and Healthcare Center, Miskolc, Hungary.

 

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POSTER VIEWING
Wine and Cheese Reception
Friday, June 11, 2010
5:00-7:00 PM - Posters

SHARED GENETIC SUSCEPTIBILITY IN SARCOIDOSIS AND CHRONIC BERYLLIUM DISEASE.  T.E. Fingerlin*1, L.J. Silvera2, L. Li1,2, L.A. Maier1,2.  1University of Colorado and 2National Jewish Health, Denver, CO.

CHANGES IN THE PERIPHERAL BLOOD TRANSCRIPTOME OF ASTHMATIC INDIVIDUALS UNDERGOING ALLERGEN INHALATION CHALLENGE.  S.J. Tebbutt1*, S.H.Y. Kam1, J. Ruan1, G.M. Gauvreau2, P.M. O’Byrne2, J.M. FitzGerald1. 1University of British Columbia, Vancouver, BC Canada; 2McMaster University, Hamilton, ON, Canada.

ANALYSIS OF GENETIC PATHWAYS WITH PRIOR INFORMATION FROM ELECTRONIC DATABASES APPLIED TO ASTHMA PHENOTYPES. D. Daley1*, B. Tripp1, D. Zamar1, 1J. Hogg iCAPTURE Center, University of British Columbia, Vancouver, BC.

POLYMORPHISM IN OSTEOPONTIN GENE (SPP1) IS ASSOCIATED WITH ASTHMA AND DECREASED LUNG FUNCTION.  S. Choudhry, J. Galanter, W. Rodriguez, J. Rodriguez-Santana, C. Eng, M. LeNoir, K. Meade, P. Avila, K. Beckman, E.G. Burchard, M. Arjomandi*,  University of California San Francisco, CA.

A MAP OF GENE EXPRESSION PATTERNS ASSOCIATED WITH TH2 INFLAMMATION IN ASTHMATIC AIRWAYS.  D. Choy1, B. Modrek2, A.R. Abbas2, S. Kummerfeld2, H.F. Clark2, L.C. Wu3, G. Fedorowicz4, Z. Modrusan4, J.V. Fahy5,6, P.G. Woodruff5,6, J. Arron1*.  1Immunology, Tissue Growth, and Repair Biomarker Discovery, Departments of 2Bioinformatics, 3Immunology, and 4Molecular Biology, Genentech, Inc., South San Francisco, CA; and 5Division of Pulmonary and Critical Care Medicine, Department of Medicine and 6Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA.

TRANSCRIPTOME ANALYSIS REVEALS A NOVEL MECHANISM FOR UNIDIRECTIONAL GLUCOSE TRANSPORT IN HUMAN AIRWAY EPITHELIA.  A. Pezzulo*1, D. Stoltz1, J. Zabner1,  1Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine.

DEVELOPMENT OF A NOVEL ASTHMA VACCINE THAT TARGETS ENDOGENOUS CYTOKINES AND CHEMOKINES.  C. Hoffman1, M. Sisco1, S. Grimes2, M. Johnson2, D. Conroy2, P. Blackburn2, G. Grunig*1.  1New York University, Department of Environmental Medicine, Tuxedo, NY, 2Mercia Pharma, Scarsdale, NY.

INTEGRATED LABEL-FREE QUANTITATIVE MASS SPECTROMETRY ANALYSIS OF THE BRONCHOALVEOLAR LAVAGE PROTEOME AND LUNG (PHOSPHO) PROTEOME IN A MODEL OF ACUTE LUNG INJURY AND THERAPY.  M.W. Foster*, E.J. Soderblom, J.W. Thompson, E.N. Potts, R.L. Auten, W.M. Foster, M.A. Moseley, H.E. Marshall. Duke University Medical Center, Durham, NC.

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IMMUNE MODULATION BY MUTANT P53 AND ONCOGENIC K-RAS ASSOCIATED WITH COOPERATIVE INDUCTION OF LUNG ADENOCARCINOMA IN MICE.  G.F. Morris*, J.F. Guenther, D.R. Herleth, Y. Wang, K. Moroz, D.A. Pociask3, B. Shan1, D.E. Sullivan2.  Program in Lung Biology, Departments of Pathology, 1Medicine, and 2Microbiology Tulane University School of Medicine, 3Department of Genetics, Louisiana State University Health Science Center New Orleans, LA.

 

PROTEOMIC PROFILING IN ARDS: EARLY DIFFERENCES BETWEEN SURVIVORS AND NON-SURVIVORS.  M. Bhargava*, T. Beckers, G. Nelsestuen, V. Kumar, P. Bitterman, D. Ingbar, C. Wendt. University of Minnesota Medical School, Minneapolis, MN.

 

MANNOSE BINDING LECTIN VARIANTS IN CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA.  M. Quasney1*, A. Sapru2, M. Dahmer1.  Department of Pediatric Critical Care, and Children’s Research Institute, Medical College of Wisconsin, Milwaukee1, WI, and Pediatric Critical Care Medicine, University of California, San Francisco2, CA.

 

EXPEDITING DIAGNOSIS OF HIV-RELATED PULMONARY HYPERTENSION FROM THE BENCH: HIV-1 NEF SEQUENCES AS GENETIC TRANSLATIONAL TOOLS.  S. Almodovar*1, J. Morelli2, M. Hakar1, J. Gilman1, B. Niemeyer1, A.C. Flores1, C. Sokas1, P.Y. Hsue2, S.C. Flores1.  1Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, 2San Francisco General Hospital, University of California, San Francisco, CA. 

 

GLOBAL MICRORNA PROFILE OF IDIOPATHIC PULMONARY FIBROSIS.  K.V. Pandit*1, J. Milosevic1, 2P.V. Benos, Ph.D., 1N. Kaminski, M.D.  1Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.  2Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

 

TRANSCRIPTIONAL ANALYSIS AND SUBCLASSIFICATION OF THE IDIOPATHIC INTERSTITIAL PNEUMONIAS.  C.D. Coldren*, I.V. Yang, E. Murphy, J. Lin, T. Fingerlin, S.M. Leach, S. Groshong, C. Cool, B. Gao, M.W. Geraci, K.K. Brown, R.M. du Bois, M.I. Schwarz, D.A. Schwartz, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, and National Jewish Health, Denver, CO.

 

SHOTGUN ANALYSIS OF INDUCED SPUTUM PROTEOME IN HEALTH AND ASTHMA.  S.A. Gharib1, E.V. Nguyen2, D.R. Goodlett2, T.S. Hallstrand1*, 1Division of Pulmonary and Critical Care Medicine and 2Department of Medicinal Chemistry, University of Washington, Seattle, WA.

 

MicroRNA SIGNATURE OF LUNG EPITHELIAL POLARITY OF ORGANOTYPIC CULTURE.  L. Cui, H. Nguyen, Y. Zhuang, S. Kantrow, E. Flemingtonn, G. Morris, B. Shan*. Tulane University of School of Medicine, New Orleans, LA.