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University of Colorado Department of Biochemistry and Molecular Genetics

Biochemistry and Molecular Genetics
 

Primary Faculty



David Bentley, PhD

Messenger RNA Production by RNA polymerase II.

Gina Clayton, PhD

Richard Davis, PhD
Programmed DNA elimination, novel RNAs, and RNA metabolism.
Cancer Evolution and Cancer Signaling Pathways.
Viral protein/host protein interactions and enzyme motions.
Quantitative and functional proteomics, extracellular matrix processing and organization.
Genomics of gene regulation.
Peptide and protein structure.
Cellular responses to DNA damage and other types of environmental stress by genetic, biochemical, and functional genomic approaches.
Mechanisms of chromatin-mediated gene silencing.
Functional genomics, glucose sensing and signaling.
Environmental and Ecological Genomics.
Protein Translation and RNA structure.
Proteasomal degradation and spinal muscular atrophy.

Protein structure, function and sequence evolution.
Robert A Sclafani, PhD
The regulation of the G1 to S phase transition of the cell cycle in yeast and mammalian cells.

James Sikela, PhD

Genome variation in human evolution and disease.

Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer.

Structural biology of membrane proteins and protein complexes.


 

 

Emeritus Faculty

 

Yeast RNA polymerases and their accessory factors.
 
The involvement of extracellular proteases in aspects of axonal growth.
 
The synthesis of a wide variety of peptides by the solidphase method.